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Antibiotic Summary Table

by Dr. Brett Margolias

TABLE 1 -- EMPIRIC ANTIBIOTIC SELECTION
		Suspected Source of Sepsis
		*Lung*	*Abdomen*	*Skin/Soft Tissue*	*Urinary Tract*	*CNS*
	Major community-acquired pathogens	Streptococcus pneumoniae Haemophilus influenzae Legionella species Chlamydia pneumoniae Pneumocystis carinii	Escherichia coli Bacteroides fragilis	Group A streptococcus Staphylococcus aureus Clostridium species Polymicrobial Enteric gram-negative rods Pseudomonas aeruginosa Anaerobes Staphylococci	Escherichia coli Klebsiella species Enterobacter species Proteus species	Streptococcus pneumoniae Neisseria meningiditis Listeria monocytogenes Escherichia coli Haemophilus influenzae
	Empiric antibiotic therapy	Macrolide and third-generation cephalopsorin or Levofloxacin	Imipenem-cilastatin or Piperacillin-tazobactam ± aminoglycoside	Vancomycin ± Imipenemin-cilastatin or Piperacillin-tazobactam	Ciprofloxacin ± aminoglycoside	Vancomycin + third-generation cephalosporin or Meropenem
	Major nosocomial pathogenes	Aerobic gram-negative bacilli	Aerobic gram-negative rods Anaerobes Candida species	Staphylococcus aureus Aerobic gram-negative rods	Aerobic gram-negative rods Enterococci	Pseudomonas aeruginosa Escherichia coli Klebsiella species Staphylococci species
	Empiric antibiotic therapy	Cefipime or Imipenem-cilastatin + aminoglycoside	Imipenem-cilastatin ± aminoglycoside or Piperacillin-tazobactam ± Amphotericin B	Vancomycin + Cefipime	Vancomycin + Cefipime	Cefipime or Meropenem + Vancomycin

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